Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model

In humans, homozygous mutations in the TPP1 gene results in loss of tripeptidyl peptidase 1 (TPP1) enzymatic activity, leading to late infantile neuronal ceroid lipofuscinoses disease. Using a mouse model that targets the Tpp1 gene and recapitulates the pathology and clinical features of the human d...

Descripción completa

Detalles Bibliográficos
Autores principales: Domowicz, Miriam S., Chan, Wen-Ching, Claudio-Vázquez, Patricia, Henry, Judith G., Ware, Christopher B., Andrade, Jorge, Dawson, Glyn, Schwartz, Nancy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475859/
https://www.ncbi.nlm.nih.gov/pubmed/31003587
http://dx.doi.org/10.1177/1759091419843393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475859/
https://www.ncbi.nlm.nih.gov/pubmed/31003587
http://dx.doi.org/10.1177/1759091419843393

Ejemplares similares