A Novel Dipeptide NGF Mimetic GK-2 Selectively Activating the PI3K/AKT Signaling Pathway Promotes the Survival of Pancreatic β-Cells in a Rat Model of Diabetes

We investigated the cytoprotective effect of a novel low-molecular-weight NGF mimetic, GK-2 (hexamethylenediamide bis-N-monosuccinyl-L-glutamyl-L-lysine), on pancreatic β-cells. The neuroprotective effect of GK-2 had been previously shown to be associated with selective activation of the PI3K/Akt si...

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Detalles Bibliográficos
Autores principales: Ostrovskaya, R. U., Ivanov, S. V., Gudasheva, T. A., Seredenin, S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475863/
https://www.ncbi.nlm.nih.gov/pubmed/31024748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475863/
https://www.ncbi.nlm.nih.gov/pubmed/31024748

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