Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

The melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their associations with body mass index (BMI) and obesity-related cardiometabolic diseases....

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Detalles Bibliográficos
Autores principales: Lotta, Luca A., Mokrosiński, Jacek, Mendes de Oliveira, Edson, Li, Chen, Sharp, Stephen J., Luan, Jian’an, Brouwers, Bas, Ayinampudi, Vikram, Bowker, Nicholas, Kerrison, Nicola, Kaimakis, Vasileios, Hoult, Diana, Stewart, Isobel D., Wheeler, Eleanor, Day, Felix R., Perry, John R.B., Langenberg, Claudia, Wareham, Nicholas J., Farooqi, I. Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476272/
https://www.ncbi.nlm.nih.gov/pubmed/31002796
http://dx.doi.org/10.1016/j.cell.2019.03.044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476272/
https://www.ncbi.nlm.nih.gov/pubmed/31002796
http://dx.doi.org/10.1016/j.cell.2019.03.044

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