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Engineering a Model Cell for Rational Tuning of GPCR Signaling

G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to respond to specific cues in their environment. However, the relationship between stimulus and response for each GPCR is difficult to predict due to diversity in natural signal transduction architecture and expression...

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Detalles Bibliográficos
Autores principales: Shaw, William M., Yamauchi, Hitoshi, Mead, Jack, Gowers, Glen-Oliver F., Bell, David J., Öling, David, Larsson, Niklas, Wigglesworth, Mark, Ladds, Graham, Ellis, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476273/
https://www.ncbi.nlm.nih.gov/pubmed/30955892
http://dx.doi.org/10.1016/j.cell.2019.02.023