A DNA aptamer reveals an allosteric site for inhibition in metallo-β-lactamases

The hydrolysis of β-lactam antibiotics by β-lactamase enzymes is the most prominent antibiotic resistance mechanism for many pathogenic bacteria. Out of this broad class of enzymes, metallo-β-lactamases are of special clinical interest because of their broad substrate specificities. Several in vitro...

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Detalles Bibliográficos
Autores principales: Khan, Nazmul H., Bui, Anthony A., Xiao, Yang, Sutton, R. Bryan, Shaw, Robert W., Wylie, Benjamin J., Latham, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476477/
https://www.ncbi.nlm.nih.gov/pubmed/31009467
http://dx.doi.org/10.1371/journal.pone.0214440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476477/
https://www.ncbi.nlm.nih.gov/pubmed/31009467
http://dx.doi.org/10.1371/journal.pone.0214440

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