Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation

Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes. Sirtuin2 (Sirt2) is an NAD(+)-dependent deacetylase that regulates several biological processes, including hepatic gluconeogenesis, as well as inflammatory pathways. We sho...

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Detalles Bibliográficos
Autores principales: Lee, Da Hyun, Lee, Buhyun, Park, Jeong Su, Lee, Yu Seol, Kim, Jin Hee, Cho, Yejin, Jo, Yoonjung, Kim, Hyun-Seok, Lee, Yong-ho, Nam, Ki Taek, Bae, Soo Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476489/
https://www.ncbi.nlm.nih.gov/pubmed/30021675
http://dx.doi.org/10.5483/BMBRep.2019.52.3.083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476489/
https://www.ncbi.nlm.nih.gov/pubmed/30021675
http://dx.doi.org/10.5483/BMBRep.2019.52.3.083

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