Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation

The role of ribosomal protein S6 (rpS6) phosphorylation in mRNA translation remains poorly understood. Here, we reveal a potential role in modulating the translation rate of chemokine (C-X-C motif) ligand 8 (CXCL8 or Interleukin 8, IL8). We observed that more CXCL8 protein was being secreted from le...

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Detalles Bibliográficos
Autores principales: Ang, Zhiwei, Koean, Ricky Abdi Gunawan, Er, Jun Zhi, Lee, Li Ting, Tam, John Kit Chung, Guo, Huili, Ding, Jeak Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476525/
https://www.ncbi.nlm.nih.gov/pubmed/30969964
http://dx.doi.org/10.1371/journal.pgen.1008077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476525/
https://www.ncbi.nlm.nih.gov/pubmed/30969964
http://dx.doi.org/10.1371/journal.pgen.1008077

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