Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells

The orphan transcription factor nuclear receptor-related 1 protein (Nurr1, also known as NR4A2) plays a key role in embryonic development and maintenance of mesencephalic dopaminergic neurons in the substantia nigra. Nurr1 deficiency is associated with Parkinson’s disease where dopaminergic neurons...

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Detalles Bibliográficos
Autores principales: Paliga, Dennis, Raudzus, Fabian, Leppla, Stephen H., Heumann, Rolf, Neumann, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476859/
https://www.ncbi.nlm.nih.gov/pubmed/30121937
http://dx.doi.org/10.1007/s12035-018-1311-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476859/
https://www.ncbi.nlm.nih.gov/pubmed/30121937
http://dx.doi.org/10.1007/s12035-018-1311-6

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