Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment

Tau aggregation is a hallmark of a group of neurodegenerative diseases termed Tauopathies. Reduction of aggregation-prone Tau has emerged as a promising therapeutic approach. Here, we show that an anti-aggregant Tau fragment (F3(ΔKPP), residues 258–360) harboring the ΔK280 mutation and two proline s...

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Detalles Bibliográficos
Autores principales: Pir, Ghulam Jeelani, Choudhary, Bikash, Kaniyappan, Senthilvelrajan, Chandupatla, Ram Reddy, Mandelkow, Eckhard, Mandelkow, Eva-Maria, Wang, Yipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476873/
https://www.ncbi.nlm.nih.gov/pubmed/30196394
http://dx.doi.org/10.1007/s12035-018-1326-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476873/
https://www.ncbi.nlm.nih.gov/pubmed/30196394
http://dx.doi.org/10.1007/s12035-018-1326-z

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