Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis

Calprotectin, the major neutrophil protein, is a critical alarmin that modulates inflammation and plays a role in host immunity by strongly binding trace metals essential for bacterial growth. It has two cysteine residues favourably positioned to act as a redox switch. Whether their oxidation occurs...

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Detalles Bibliográficos
Autores principales: Hoskin, Teagan S., Crowther, Jennifer M., Cheung, Jeanette, Epton, Michael J., Sly, Peter D., Elder, Peter A., Dobson, Renwick C.J., Kettle, Anthony J., Dickerhof, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477633/
https://www.ncbi.nlm.nih.gov/pubmed/31015146
http://dx.doi.org/10.1016/j.redox.2019.101202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477633/
https://www.ncbi.nlm.nih.gov/pubmed/31015146
http://dx.doi.org/10.1016/j.redox.2019.101202

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