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Oxidative cross-linking of calprotectin occurs in vivo, altering its structure and susceptibility to proteolysis
Calprotectin, the major neutrophil protein, is a critical alarmin that modulates inflammation and plays a role in host immunity by strongly binding trace metals essential for bacterial growth. It has two cysteine residues favourably positioned to act as a redox switch. Whether their oxidation occurs...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477633/ https://www.ncbi.nlm.nih.gov/pubmed/31015146 http://dx.doi.org/10.1016/j.redox.2019.101202 |