Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development

The TCL1 mouse model is widely used to study pathophysiology, clonal evolution, and drug sensitivity or resistance of chronic lymphocytic leukemia (CLL). By performing whole exome sequencing, we present the genetic landscape of primary tumors from TCL1 mice and of TCL1 tumors serially transplanted i...

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Detalles Bibliográficos
Autores principales: Zaborsky, Nadja, Gassner, Franz J., Höpner, Jan P., Schubert, Maria, Hebenstreit, Daniel, Stark, Richard, Asslaber, Daniela, Steiner, Markus, Geisberger, Roland, Greil, Richard, Egle, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477797/
https://www.ncbi.nlm.nih.gov/pubmed/30262843
http://dx.doi.org/10.1038/s41375-018-0260-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477797/
https://www.ncbi.nlm.nih.gov/pubmed/30262843
http://dx.doi.org/10.1038/s41375-018-0260-4

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