6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver

Liver aging is associated with age-related histopathological and functional changes that significantly enhance the risk of numerous diseases or disorders developing in elderly populations. 6-Bromoindirubin-3′-oxime (6BIO), a potent inhibitor of glycogen synthase kinase-3 (GSK-3), has been implicated...

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Detalles Bibliográficos
Autores principales: Guo, Donghao, Shen, Yun, Li, Wei, Li, Qinjie, Zhao, Yu, Pan, Chenhao, Chen, Bi, Zhong, Yuan, Miao, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477879/
https://www.ncbi.nlm.nih.gov/pubmed/31057395
http://dx.doi.org/10.3389/fphar.2019.00320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477879/
https://www.ncbi.nlm.nih.gov/pubmed/31057395
http://dx.doi.org/10.3389/fphar.2019.00320

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