MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders

BACKGROUND: Patients with Opitz GBBB syndrome present with a variable array of developmental defects including craniofacial, cardiac, and genital anomalies. Mutations in the X-linked MID1 gene, which encodes a microtubule-binding protein, have been found in ~50% of Opitz GBBB syndrome patients consi...

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Detalles Bibliográficos
Autores principales: Short, Kieran M, Hopwood, Blair, Yi, Zou, Cox, Timothy C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64779/
https://www.ncbi.nlm.nih.gov/pubmed/11806752
http://dx.doi.org/10.1186/1471-2121-3-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64779/
https://www.ncbi.nlm.nih.gov/pubmed/11806752
http://dx.doi.org/10.1186/1471-2121-3-1

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