IRF3 and Type I Interferons Fuel a Fatal Response to Myocardial Infarction

Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections(1) and cancer(2), but excessive IRF3 activation and type I IFN production cause auto-inflammatory conditions such as Aicardi Goutieres Syndrome(3,4) and STING-associated vasculopathy of infancy (SAVI)(3)....

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Detalles Bibliográficos
Autores principales: King, Kevin R., Aguirre, Aaron D., Ye, Yu-Xiang, Sun, Yuan, Roh, Jason D., Ng, Richard P., Kohler, Rainer H., Arlauckas, Sean P., Iwamoto, Yoshiko, Savol, Andrej, Sadreyev, Ruslan I., Kelly, Mark, Fitzgibbons, Timothy P., Fitzgerald, Katherine A., Mitchison, Timothy, Libby, Peter, Nahrendorf, Matthias, Weissleder, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477926/
https://www.ncbi.nlm.nih.gov/pubmed/29106401
http://dx.doi.org/10.1038/nm.4428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477926/
https://www.ncbi.nlm.nih.gov/pubmed/29106401
http://dx.doi.org/10.1038/nm.4428

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