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Reconciling high-throughput gene essentiality data with metabolic network reconstructions
The identification of genes essential for bacterial growth and survival represents a promising strategy for the discovery of antimicrobial targets. Essential genes can be identified on a genome-scale using transposon mutagenesis approaches; however, variability between screens and challenges with in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478342/ https://www.ncbi.nlm.nih.gov/pubmed/30973869 http://dx.doi.org/10.1371/journal.pcbi.1006507 |