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FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells
Maintenance of a healthy proteome is essential for cellular homeostasis and loss of proteostasis is associated with tissue dysfunction and neurodegenerative disease. The mechanisms that support proteostasis in healthy cells and how they become defective during aging or in disease states are not full...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478346/ https://www.ncbi.nlm.nih.gov/pubmed/30973875 http://dx.doi.org/10.1371/journal.pgen.1008097 |