In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus

In Streptomyces clavuligerus, the gene cluster involved in the biosynthesis of the clinically used β-lactamase inhibitor clavulanic acid contains a gene (orf12 or cpe) encoding a protein with a C-terminal class A β-lactamase-like domain. The cpe gene is essential for clavulanic acid production, and...

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Detalles Bibliográficos
Autores principales: Srivastava, Santosh K., King, Kelcey S., AbuSara, Nader F., Malayny, Chelsea J., Piercey, Brandon M., Wilson, Jaime A., Tahlan, Kapil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478378/
https://www.ncbi.nlm.nih.gov/pubmed/31013337
http://dx.doi.org/10.1371/journal.pone.0215960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478378/
https://www.ncbi.nlm.nih.gov/pubmed/31013337
http://dx.doi.org/10.1371/journal.pone.0215960

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