DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination

The control of p53 protein stability is critical to its tumor suppressor functions. The CREB binding protein (CBP) transcriptional co-activator co-operates with MDM2 to maintain normally low physiological p53 levels in cells via exclusively cytoplasmic E4 polyubiquitination activity. Using mass spec...

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Detalles Bibliográficos
Autores principales: Akande, Oluwatoyin E., Damle, Priyadarshan K., Pop, Marius, Sherman, Nicholas E., Szomju, Barbara B., Litovchick, Larisa V., Grossman, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478392/
https://www.ncbi.nlm.nih.gov/pubmed/30893604
http://dx.doi.org/10.1016/j.celrep.2019.02.076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478392/
https://www.ncbi.nlm.nih.gov/pubmed/30893604
http://dx.doi.org/10.1016/j.celrep.2019.02.076

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