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DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination
The control of p53 protein stability is critical to its tumor suppressor functions. The CREB binding protein (CBP) transcriptional co-activator co-operates with MDM2 to maintain normally low physiological p53 levels in cells via exclusively cytoplasmic E4 polyubiquitination activity. Using mass spec...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478392/ https://www.ncbi.nlm.nih.gov/pubmed/30893604 http://dx.doi.org/10.1016/j.celrep.2019.02.076 |