IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability

Interleukin-15 (IL-15) and IL-2 drive T-cell malignancies including T-cell large granular lymphocyte leukemia (T-LGLL) and HTLV-1 driven adult T-cell leukemia (ATL). Both cytokines share common γ-chain receptors and downstream signaling pathways. T-LGLL is characterized by clonal expansion of cytoto...

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Detalles Bibliográficos
Autores principales: Wang, T. Tiffany, Yang, Jun, Zhang, Yong, Zhang, Meili, Dubois, Sigrid, Conlon, Kevin C., Tagaya, Yutaka, Hamele, Cait E., Dighe, Shubha, Olson, Thomas L., Feith, David J., Azimi, Nazli, Waldmann, Thomas A., Loughran, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478569/
https://www.ncbi.nlm.nih.gov/pubmed/30353031
http://dx.doi.org/10.1038/s41375-018-0290-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478569/
https://www.ncbi.nlm.nih.gov/pubmed/30353031
http://dx.doi.org/10.1038/s41375-018-0290-y

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