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Outcome-adaptive randomization in clinical trials: issues of participant welfare and autonomy

Outcome-adaptive randomization (OAR) has been proposed as a corrective to certain ethical difficulties inherent in the traditional randomized clinical trial (RCT) using fixed-ratio randomization. In particular, it has been suggested that OAR redresses the balance between individual and collective et...

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Detalles Bibliográficos
Autor principal: Sim, Julius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478640/
https://www.ncbi.nlm.nih.gov/pubmed/30778720
http://dx.doi.org/10.1007/s11017-019-09481-0