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Outcome-adaptive randomization in clinical trials: issues of participant welfare and autonomy
Outcome-adaptive randomization (OAR) has been proposed as a corrective to certain ethical difficulties inherent in the traditional randomized clinical trial (RCT) using fixed-ratio randomization. In particular, it has been suggested that OAR redresses the balance between individual and collective et...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478640/ https://www.ncbi.nlm.nih.gov/pubmed/30778720 http://dx.doi.org/10.1007/s11017-019-09481-0 |