RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36

DHX36 is a DEAH-box helicase that resolves parallel G-quadruplex structures formed in DNA and RNA. The recent co-crystal structure of DHX36 bound G4-DNA revealed an intimate contact, but did not address the role of ATP hydrolysis in G4 resolving activity. Here, we demonstrate that unlike on G4-DNA,...

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Detalles Bibliográficos
Autores principales: Tippana, Ramreddy, Chen, Michael C., Demeshkina, Natalia A., Ferré-D’Amaré, Adrian R., Myong, Sua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478676/
https://www.ncbi.nlm.nih.gov/pubmed/31015431
http://dx.doi.org/10.1038/s41467-019-09802-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478676/
https://www.ncbi.nlm.nih.gov/pubmed/31015431
http://dx.doi.org/10.1038/s41467-019-09802-w

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