A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice

DNA methyltransferases (DNMTs) deposit DNA methylation, which regulates gene expression and is essential for mammalian development. Histone post-translational modifications modulate the recruitment and activity of DNMTs. The PWWP domains of DNMT3A and DNMT3B are posited to interact with histone 3 ly...

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Detalles Bibliográficos
Autores principales: Sendžikaitė, Gintarė, Hanna, Courtney W., Stewart-Morgan, Kathleen R., Ivanova, Elena, Kelsey, Gavin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478690/
https://www.ncbi.nlm.nih.gov/pubmed/31015495
http://dx.doi.org/10.1038/s41467-019-09713-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478690/
https://www.ncbi.nlm.nih.gov/pubmed/31015495
http://dx.doi.org/10.1038/s41467-019-09713-w

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