ATP-binding Cassette Transporters Substantially Reduce Estimates of ALDH-positive Cancer Cells based on Aldefluor and AldeRed588 Assays

Aldehyde dehydrogenase (ALDH) assays measure the accumulated fluorescence of enzyme products. However, cancer cells frequently co-express ALDH and ATP-binding cassette (ABC) transporters, which might mediate efflux of ALDH assay reagents. We demonstrate expression of active multidrug resistance prot...

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Detalles Bibliográficos
Autores principales: Park, Jin Won, Jung, Kyung-Ho, Byun, Youngjoo, Lee, Jin Hee, Moon, Seung Hwan, Cho, Young Seok, Lee, Kyung-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478741/
https://www.ncbi.nlm.nih.gov/pubmed/31015586
http://dx.doi.org/10.1038/s41598-019-42954-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478741/
https://www.ncbi.nlm.nih.gov/pubmed/31015586
http://dx.doi.org/10.1038/s41598-019-42954-9

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