SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles

Primordial follicles, consisting of granulosa cell (GC)-enveloped oocytes are maintained in a state of developmental arrest until activated to grow. The mechanism that operates to maintain this arrested state in GCs is currently unknown. Here, we show the TGFβ-activated transcription factor SMAD3 is...

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Detalles Bibliográficos
Autores principales: Granados-Aparici, Sofia, Hardy, Kate, Franks, Stephen, Sharum, Isam B., Waite, Sarah L., Fenwick, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478827/
https://www.ncbi.nlm.nih.gov/pubmed/31015579
http://dx.doi.org/10.1038/s41598-019-42878-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478827/
https://www.ncbi.nlm.nih.gov/pubmed/31015579
http://dx.doi.org/10.1038/s41598-019-42878-4

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