Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs

A novel class of small non-coding RNAs called DNA damage response RNAs (DDRNAs) generated at DNA double-strand breaks (DSBs) in a DROSHA- and DICER-dependent manner has been shown to regulate the DNA damage response (DDR). Similar molecules were also reported to guide DNA repair. Here, we show that...

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Detalles Bibliográficos
Autores principales: Gioia, Ubaldo, Francia, Sofia, Cabrini, Matteo, Brambillasca, Silvia, Michelini, Flavia, Jones-Weinert, Corey W., d’Adda di Fagagna, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478851/
https://www.ncbi.nlm.nih.gov/pubmed/31015566
http://dx.doi.org/10.1038/s41598-019-42892-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478851/
https://www.ncbi.nlm.nih.gov/pubmed/31015566
http://dx.doi.org/10.1038/s41598-019-42892-6

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