Cargando…

Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs

A novel class of small non-coding RNAs called DNA damage response RNAs (DDRNAs) generated at DNA double-strand breaks (DSBs) in a DROSHA- and DICER-dependent manner has been shown to regulate the DNA damage response (DDR). Similar molecules were also reported to guide DNA repair. Here, we show that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gioia, Ubaldo, Francia, Sofia, Cabrini, Matteo, Brambillasca, Silvia, Michelini, Flavia, Jones-Weinert, Corey W., d’Adda di Fagagna, Fabrizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478851/ https://www.ncbi.nlm.nih.gov/pubmed/31015566 http://dx.doi.org/10.1038/s41598-019-42892-6

Ejemplares similares

DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors
por: Francia, Sofia, et al.
Publicado: (2016)

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
por: Michelini, Flavia, et al.
Publicado: (2017)

Site-specific DICER and DROSHA RNA products control the DNA damage response
por: Francia, Sofia, et al.
Publicado: (2012)

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
por: Rossiello, Francesca, et al.
Publicado: (2017)

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining
por: Cabrini, Matteo, et al.
Publicado: (2021)

DNA damage response at telomeres boosts the transcription of SARS‐CoV‐2 receptor ACE2 during aging
por: Sepe, Sara, et al.
Publicado: (2021)

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks
por: Iannelli, Fabio, et al.
Publicado: (2017)

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage response factors
por: Pessina, Fabio, et al.
Publicado: (2019)

A novel single‐cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues
por: Galbiati, Alessandro, et al.
Publicado: (2017)

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
por: Aguado, Julio, et al.
Publicado: (2019)

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation
por: Ogrunc, M, et al.
Publicado: (2014)

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing
por: Rossiello, Francesca, et al.
Publicado: (2014)

Detection of Telomeric DNA:RNA Hybrids Using TeloDRIP-qPCR
por: Rosso, Ilaria, et al.
Publicado: (2020)

Neural stem cells exposed to BrdU lose their global DNA methylation and undergo astrocytic differentiation
por: Schneider, Leonid, et al.
Publicado: (2012)

Need telomere maintenance? Call 911
por: Francia, Sofia, et al.
Publicado: (2007)

DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT
por: Schneider, Leonid, et al.
Publicado: (2013)

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
por: Sharma, Sheetal, et al.
Publicado: (2021)

P1327: INHIBITING TELOMERIC DNA DAMAGE RESPONSE AS A NEW THERAPEUTIC STRATEGY TO REJUVENATE THE AGEING HEMATOPOIETIC SYSTEM
por: Oppezzo, Alessia, et al.
Publicado: (2023)

Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs
por: Rosso, Ilaria, et al.
Publicado: (2023)

SARS-CoV-2 infection induces DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
por: Gioia, Ubaldo, et al.
Publicado: (2023)

Never-ageing cellular senescence
por: Ogrunc, Müge, et al.
Publicado: (2011)

Pharmacological inhibition of EZH2 combined with DNA-damaging agents interferes with the DNA damage response in MM cells
por: Xu, Li, et al.
Publicado: (2019)

DNA damage response and repair data with pharmacological modulators of Tousled
por: Timiri Shanmugam, Prakash Srinivasan, et al.
Publicado: (2016)

DNA Damage Response
por: Oksenych, Valentyn, et al.
Publicado: (2021)

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex
por: Adamowicz, Marek, et al.
Publicado: (2016)

Engineering a DNA damage response without DNA damage
por: Yeung, ManTek, et al.
Publicado: (2008)

DNA Damage and DNA Damage Response in Chronic Myeloid Leukemia
por: Popp, Henning D., et al.
Publicado: (2020)

Interplay of space radiation and microgravity in DNA damage and DNA damage response
por: Moreno-Villanueva, María, et al.
Publicado: (2017)

AATF/Che-1—An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis
por: Kaiser, Rainer W. J., et al.
Publicado: (2020)

Cellular responses to DNA damage.
por: Walker, G C, et al.
Publicado: (1985)

Sumoylation and the DNA Damage Response
por: Cremona, Catherine A., et al.
Publicado: (2012)

Autophagy in DNA Damage Response
por: Czarny, Piotr, et al.
Publicado: (2015)

SUMO in the DNA damage response
por: Hendriks, Ivo A., et al.
Publicado: (2015)

Scorpins in the DNA Damage Response
por: Palmieri, Dario, et al.
Publicado: (2018)

DNA damage responses in ageing
por: da Silva, Paulo F. L., et al.
Publicado: (2019)

The Mitochondrial Response to DNA Damage
por: Rong, Ziye, et al.
Publicado: (2021)

Medulloblastoma and the DNA Damage Response
por: McSwain, Leon F., et al.
Publicado: (2022)

Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53
por: Venkata Narayanan, Ishwarya, et al.
Publicado: (2017)

DNA Damage Response (DDR) and DNA Repair
por: Vernì, Fiammetta
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_29ctettn1gcglp52d5360dslgk