Ceramides bind VDAC2 to trigger mitochondrial apoptosis

Ceramides draw wide attention as tumor suppressor lipids that act directly on mitochondria to trigger apoptotic cell death. However, molecular details of the underlying mechanism are largely unknown. Using a photoactivatable ceramide probe, we here identify the voltage-dependent anion channels VDAC1...

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Detalles Bibliográficos
Autores principales: Dadsena, Shashank, Bockelmann, Svenja, Mina, John G. M., Hassan, Dina G., Korneev, Sergei, Razzera, Guilherme, Jahn, Helene, Niekamp, Patrick, Müller, Dagmar, Schneider, Markus, Tafesse, Fikadu G., Marrink, Siewert J., Melo, Manuel N., Holthuis, Joost C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478893/
https://www.ncbi.nlm.nih.gov/pubmed/31015432
http://dx.doi.org/10.1038/s41467-019-09654-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478893/
https://www.ncbi.nlm.nih.gov/pubmed/31015432
http://dx.doi.org/10.1038/s41467-019-09654-4

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