Design, synthesis and biological evaluation of benzoxazolinone-containing 1,3,4-thiadiazoles as TNF-α inhibitors

A library of nineteen benzoxazolinone-based 1,3,4-thiadiazoles has been synthesized and screened for their anti-inflammatory activity. The compound 1f exhibited a potent anti-inflammatory activity with an inhibition of 65.83% and 32.50% after 3 h and 5 h respectively. It also exhibited a significant...

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Detalles Bibliográficos
Autores principales: Haider, Saqlain, Alam, Mohammad Sarwar, Hamid, Hinna, Dhulap, Abhijeet, Kumar, Deepak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479203/
https://www.ncbi.nlm.nih.gov/pubmed/31049428
http://dx.doi.org/10.1016/j.heliyon.2019.e01503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479203/
https://www.ncbi.nlm.nih.gov/pubmed/31049428
http://dx.doi.org/10.1016/j.heliyon.2019.e01503

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