New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2

The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (ABT-199) for the treatment of chronic lymphocytic l...

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Detalles Bibliográficos
Autores principales: Hamdy, Rania, Elseginy, Samia A., Ziedan, Noha I., Jones, Arwyn T., Westwell, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479519/
https://www.ncbi.nlm.nih.gov/pubmed/30986908
http://dx.doi.org/10.3390/molecules24071274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479519/
https://www.ncbi.nlm.nih.gov/pubmed/30986908
http://dx.doi.org/10.3390/molecules24071274

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