Studies on the Interaction between Poly-Phosphane Gold(I) Complexes and Dihydrofolate Reductase: An Interplay with Nicotinamide Adenine Dinucleotide Cofactor

A class of gold(I) phosphane complexes have been identified as inhibitors of dihydrofolate reductase (DHFR) from E. coli, an enzyme that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate (THF), using NADPH as a coenzyme. In this work, to comprehend the nature of the interaction at t...

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Detalles Bibliográficos
Autores principales: Pucciarelli, Stefania, Vincenzetti, Silvia, Ricciutelli, Massimo, Simon, Oumarou Camille, Ramadori, Anna Teresa, Luciani, Lorenzo, Galassi, Rossana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479694/
https://www.ncbi.nlm.nih.gov/pubmed/30979096
http://dx.doi.org/10.3390/ijms20071802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479694/
https://www.ncbi.nlm.nih.gov/pubmed/30979096
http://dx.doi.org/10.3390/ijms20071802

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