Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

Human thymidylate synthase (hTS) is pivotal for cell survival and proliferation, indeed it provides the only synthetic source of dTMP, required for DNA biosynthesis. hTS represents a validated target for anticancer chemotherapy. However, active site-targeting drugs towards hTS have limitations conne...

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Detalles Bibliográficos
Autores principales: Pozzi, Cecilia, Ferrari, Stefania, Luciani, Rosaria, Costi, Maria Paola, Mangani, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479699/
https://www.ncbi.nlm.nih.gov/pubmed/30959951
http://dx.doi.org/10.3390/molecules24071362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479699/
https://www.ncbi.nlm.nih.gov/pubmed/30959951
http://dx.doi.org/10.3390/molecules24071362

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