High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-N-acyl-β-d-Glucopyranosylamines as Glycogen Phosphorylase Inhibitors

Structure-based design and synthesis of two biphenyl-N-acyl-β-d-glucopyranosylamine derivatives as well as their assessment as inhibitors of human liver glycogen phosphorylase (hlGPa, a pharmaceutical target for type 2 diabetes) is presented. X-ray crystallography revealed the importance of structur...

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Detalles Bibliográficos
Autores principales: Fischer, Thomas, Koulas, Symeon M., Tsagkarakou, Anastasia S., Kyriakis, Efthimios, Stravodimos, George A., Skamnaki, Vassiliki T., Liggri, Panagiota G.V., Zographos, Spyros E., Riedl, Rainer, Leonidas, Demetres D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479789/
https://www.ncbi.nlm.nih.gov/pubmed/30987252
http://dx.doi.org/10.3390/molecules24071322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479789/
https://www.ncbi.nlm.nih.gov/pubmed/30987252
http://dx.doi.org/10.3390/molecules24071322

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