Structure-Based Design of Novel Benzimidazole Derivatives as Pin1 Inhibitors

Peptidyl-prolyl cis/trans isomerase Pin1 plays a key role in amplifying and translating multiple oncogenic signaling pathways during oncogenesis. The blockade of Pin1 provided a unique way of disrupting multiple oncogenic pathways and inducing apoptosis. Aiming to develop potent Pin1 inhibitors, a s...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shuxiang, Guan, Lihong, Zang, Jie, Xing, Kun, Zhang, Jian, Liu, Dan, Zhao, Linxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479814/
https://www.ncbi.nlm.nih.gov/pubmed/30934730
http://dx.doi.org/10.3390/molecules24071198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479814/
https://www.ncbi.nlm.nih.gov/pubmed/30934730
http://dx.doi.org/10.3390/molecules24071198

Ejemplares similares