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Structure-Based Design of Novel Benzimidazole Derivatives as Pin1 Inhibitors

Peptidyl-prolyl cis/trans isomerase Pin1 plays a key role in amplifying and translating multiple oncogenic signaling pathways during oncogenesis. The blockade of Pin1 provided a unique way of disrupting multiple oncogenic pathways and inducing apoptosis. Aiming to develop potent Pin1 inhibitors, a s...

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Detalles Bibliográficos
Autores principales:	Wang, Shuxiang, Guan, Lihong, Zang, Jie, Xing, Kun, Zhang, Jian, Liu, Dan, Zhao, Linxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479814/ https://www.ncbi.nlm.nih.gov/pubmed/30934730 http://dx.doi.org/10.3390/molecules24071198

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