PEG-OligoRNA Hybridization of mRNA for Developing Sterically Stable Lipid Nanoparticles toward In Vivo Administration

Lipid nanoparticles (LNPs) exhibit high potential as carriers of messenger RNA (mRNA). However, the arduous preparation process of mRNA-loaded LNPs remains a huge obstacle for their widespread clinical application. Herein, we tackled this issue by mRNA PEGylation through hybridization with polyethyl...

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Detalles Bibliográficos
Autores principales: Kurimoto, Shota, Yoshinaga, Naoto, Igarashi, Kazunori, Matsumoto, Yu, Cabral, Horacio, Uchida, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479949/
https://www.ncbi.nlm.nih.gov/pubmed/30987102
http://dx.doi.org/10.3390/molecules24071303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479949/
https://www.ncbi.nlm.nih.gov/pubmed/30987102
http://dx.doi.org/10.3390/molecules24071303

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