In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from Corydalis cava (Papaveraceae). Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and butyrylcholinesterase (hBChE) were evaluated with the Ellman’s sp...

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Detalles Bibliográficos
Autores principales: Chlebek, Jakub, Korábečný, Jan, Doležal, Rafael, Štěpánková, Šárka, Pérez, Daniel I., Hošťálková, Anna, Opletal, Lubomír, Cahlíková, Lucie, Macáková, Kateřina, Kučera, Tomáš, Hrabinová, Martina, Jun, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480038/
https://www.ncbi.nlm.nih.gov/pubmed/30959739
http://dx.doi.org/10.3390/molecules24071340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480038/
https://www.ncbi.nlm.nih.gov/pubmed/30959739
http://dx.doi.org/10.3390/molecules24071340

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