Optimisation of a key cross-coupling reaction towards the synthesis of a promising antileishmanial compound

During the course of a research program aimed at identifying novel antileishmanial compounds, a multi-gram synthesis of N-(trans-4-((4-methoxy-3-((R)-3-methylmorpholino)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)-2-methylpropane-1-sulfonamide ((R)-1) was required. This letter describes optim...

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Detalles Bibliográficos
Autores principales: Velasco, Raul F., Guerrero, César, Fra, Gloria, Moure, Alejandra, Miguel-Siles, Juan, Quesada-Campos, Maria Teresa, Ruiz-Gomez, Jose Ramon, Gilbert, Ian H., Thomas, Michael G., Miles, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480136/
https://www.ncbi.nlm.nih.gov/pubmed/31057189
http://dx.doi.org/10.1016/j.tetlet.2019.03.068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480136/
https://www.ncbi.nlm.nih.gov/pubmed/31057189
http://dx.doi.org/10.1016/j.tetlet.2019.03.068

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