Possible Role of the Ca(2+)/Mn(2+) P-Type ATPase Pmr1p on Artemisinin Toxicity through an Induction of Intracellular Oxidative Stress

Artemisinins are widely used to treat Plasmodium infections due to their high clinical efficacy; however, the antimalarial mechanism of artemisinin remains unresolved. Mutations in P. falciparum ATPase6 (PfATP6), a sarcoplasmic endoplasmic reticulum Ca(2+)-transporting ATPase, are associated with in...

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Detalles Bibliográficos
Autores principales: Pongwattanakewin, Onnicha, Phyu, The, Suesattayapirom, Suchanya, Jensen, Laran T., Jensen, Amornrat N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480206/
https://www.ncbi.nlm.nih.gov/pubmed/30934859
http://dx.doi.org/10.3390/molecules24071233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480206/
https://www.ncbi.nlm.nih.gov/pubmed/30934859
http://dx.doi.org/10.3390/molecules24071233

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