The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines

The recent developments in asymmetric A(3) (aldehyde–alkyne–amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing...

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Detalles Bibliográficos
Autores principales: Mo, Jia-Nan, Su, Junqi, Zhao, Jiannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480255/
https://www.ncbi.nlm.nih.gov/pubmed/30925732
http://dx.doi.org/10.3390/molecules24071216
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author Mo, Jia-Nan
Su, Junqi
Zhao, Jiannan
author_facet Mo, Jia-Nan
Su, Junqi
Zhao, Jiannan
author_sort Mo, Jia-Nan
collection PubMed
description The recent developments in asymmetric A(3) (aldehyde–alkyne–amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building blocks.
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spelling pubmed-64802552019-04-30 The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines Mo, Jia-Nan Su, Junqi Zhao, Jiannan Molecules Review The recent developments in asymmetric A(3) (aldehyde–alkyne–amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building blocks. MDPI 2019-03-28 /pmc/articles/PMC6480255/ /pubmed/30925732 http://dx.doi.org/10.3390/molecules24071216 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mo, Jia-Nan
Su, Junqi
Zhao, Jiannan
The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_full The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_fullStr The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_full_unstemmed The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_short The Asymmetric A(3)(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines
title_sort asymmetric a(3)(aldehyde–alkyne–amine) coupling: highly enantioselective access to propargylamines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480255/
https://www.ncbi.nlm.nih.gov/pubmed/30925732
http://dx.doi.org/10.3390/molecules24071216
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