Bioreactor-Controlled Physoxia Regulates TGF-β Signaling to Alter Extracellular Matrix Synthesis by Human Chondrocytes

Culturing articular chondrocytes under physiological oxygen tension exerts positive effects on their extracellular matrix synthesis. The underlying molecular mechanisms which enhance the chondrocytic phenotype are, however, still insufficiently elucidated. The TGF-β superfamily of growth factors, an...

Descripción completa

Detalles Bibliográficos
Autores principales: Jahr, Holger, Gunes, Seval, Kuhn, Annika-Ricarda, Nebelung, Sven, Pufe, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480267/
https://www.ncbi.nlm.nih.gov/pubmed/30959909
http://dx.doi.org/10.3390/ijms20071715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480267/
https://www.ncbi.nlm.nih.gov/pubmed/30959909
http://dx.doi.org/10.3390/ijms20071715

Ejemplares similares