Hydrophobic Amines and Their Guanidine Analogues Modulate Activation and Desensitization of ASIC3

Acid-sensing ion channel 3 (ASIC3) is an important member of the acid-sensing ion channels family, which is widely expressed in the peripheral nervous system and contributes to pain sensation. ASICs are targeted by various drugs and toxins. However, mechanisms and structural determinants of ligands’...

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Detalles Bibliográficos
Autores principales: Shteinikov, Vasilii Y, Potapieva, Natalia N, Gmiro, Valery E, Tikhonov, Denis B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480424/
https://www.ncbi.nlm.nih.gov/pubmed/30959896
http://dx.doi.org/10.3390/ijms20071713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480424/
https://www.ncbi.nlm.nih.gov/pubmed/30959896
http://dx.doi.org/10.3390/ijms20071713

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