Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease

Twelve derivatives 1a–1m of the β-crinane-type alkaloid haemanthamine were developed. All the semisynthetic derivatives were studied for their inhibitory potential against both acetylcholinesterase and butyrylcholinesterase. In addition, glycogen synthase kinase 3β (GSK-3β) inhibition potency was ev...

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Detalles Bibliográficos
Autores principales: Kohelová, Eliška, Peřinová, Rozálie, Maafi, Negar, Korábečný, Jan, Hulcová, Daniela, Maříková, Jana, Kučera, Tomáš, Martínez González, Loreto, Hrabinova, Martina, Vorčáková, Katarina, Nováková, Lucie, De Simone, Angela, Havelek, Radim, Cahlíková, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480460/
https://www.ncbi.nlm.nih.gov/pubmed/30987121
http://dx.doi.org/10.3390/molecules24071307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480460/
https://www.ncbi.nlm.nih.gov/pubmed/30987121
http://dx.doi.org/10.3390/molecules24071307

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