Ponatinib Inhibits Proliferation and Induces Apoptosis of Liver Cancer Cells, but Its Efficacy Is Compromised by Its Activation on PDK1/Akt/mTOR Signaling

Ponatinib is a multi-target protein tyrosine kinase inhibitor, and its effects on hepatocellular carcinoma cells have not been previously explored. In the present study, we investigated its effects on hepatocellular carcinoma cell growth and the underlying mechanisms. Toward SK-Hep-1 and SNU-423 cel...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Mu, Xiuli, Wang, Xuan, Zhang, Chan, Zhang, Lina, Yu, Baofeng, Sun, Gongqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480565/
https://www.ncbi.nlm.nih.gov/pubmed/30959969
http://dx.doi.org/10.3390/molecules24071363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480565/
https://www.ncbi.nlm.nih.gov/pubmed/30959969
http://dx.doi.org/10.3390/molecules24071363

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