Quick and Sensitive UPLC-ESI-MS/MS Method for Simultaneous Estimation of Sofosbuvir and Its Metabolite in Human Plasma

A simple, fast and highly sensitive RP-UPLC-MS/MS method was developed and validated for the simultaneous determination of sofosbuvir (SR) and its metabolite GS331007 in human plasma using ketotifen as an internal standard (IS). The separation was achieved on Acquity UPLC BEH C(18) (50 × 2.1 mm, i.d...

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Detalles Bibliográficos
Autores principales: Semreen, Mohammad H., Alniss, Hasan Y., Mousa, Muath K., Aboul-Enein, Hassan Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480583/
https://www.ncbi.nlm.nih.gov/pubmed/30987096
http://dx.doi.org/10.3390/molecules24071302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480583/
https://www.ncbi.nlm.nih.gov/pubmed/30987096
http://dx.doi.org/10.3390/molecules24071302

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