Cargando…

Quick and Sensitive UPLC-ESI-MS/MS Method for Simultaneous Estimation of Sofosbuvir and Its Metabolite in Human Plasma

A simple, fast and highly sensitive RP-UPLC-MS/MS method was developed and validated for the simultaneous determination of sofosbuvir (SR) and its metabolite GS331007 in human plasma using ketotifen as an internal standard (IS). The separation was achieved on Acquity UPLC BEH C(18) (50 × 2.1 mm, i.d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Semreen, Mohammad H., Alniss, Hasan Y., Mousa, Muath K., Aboul-Enein, Hassan Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480583/ https://www.ncbi.nlm.nih.gov/pubmed/30987096 http://dx.doi.org/10.3390/molecules24071302

Ejemplares similares

Analysis of Flavonoid Metabolites in Buckwheat Leaves Using UPLC-ESI-MS/MS
por: Li, Jing, et al.
Publicado: (2019)

Analysis of Flavonoid Metabolites in Chaenomeles Petals Using UPLC-ESI-MS/MS
por: Shen, Ting, et al.
Publicado: (2020)

Analysis of Flavonoid Metabolites in Citrus Peels (Citrus reticulata “Dahongpao”) Using UPLC-ESI-MS/MS
por: Wang, Fu, et al.
Publicado: (2019)

UPLC-ESI-MS/MS-Based Widely Targeted Metabolomics Analysis of Wood Metabolites in Teak (Tectona grandis)
por: Yang, Guang, et al.
Publicado: (2020)

Analysis of metabolites in young and mature Docynia delavayi (Franch.) Schneid leaves using UPLC-ESI-MS/MS
por: Xia, Xi, et al.
Publicado: (2022)

Identification of Secondary Metabolites from the Mangrove-Endophyte Lasiodiplodia iranensis F0619 by UPLC-ESI-MS/MS
por: Delgado Gómez, Lizbeth M., et al.
Publicado: (2023)

Analysis of Flavonoid Metabolites in Citrus reticulata ‘Chachi’ at Different Collection Stages Using UPLC-ESI-MS/MS
por: Chen, Yuting, et al.
Publicado: (2023)

A method for the quantitative determination of glycerophospholipid regioisomers by UPLC-ESI-MS/MS
por: Wozny, Katharina, et al.
Publicado: (2018)

UPLC-ESI-MRM/MS for Absolute Quantification and MS/MS Structural Elucidation of Six Specialized Pyranonaphthoquinone Metabolites From Ventilago harmandiana
por: Limjiasahapong, Suphitcha, et al.
Publicado: (2021)

UPLC–PDA‐ESI–QTOF–MS/MS and GC‐MS analysis of Iranian Dracocephalum moldavica L.
por: Fattahi, Azin, et al.
Publicado: (2021)

Metabolic Variations of Flavonoids in Leaves of T. media and T. mairei Obtained by UPLC-ESI-MS/MS
por: Wang, Tao, et al.
Publicado: (2019)

Development of a Proton-Enhanced ESI UPLC-MS/MS Method for the Determination of Tetrodotoxin
por: Li, Tong, et al.
Publicado: (2022)

UPLC-MS/MS Method for Simultaneous Determination of Three Major Metabolites of Mequindox in Holothurian
por: Liu, Huihui, et al.
Publicado: (2018)

Comprehensive Investigation of Moringa oleifera from Different Regions by Simultaneous Determination of 11 Polyphenols Using UPLC-ESI-MS/MS
por: Zhu, Yanqin, et al.
Publicado: (2020)

Rapid characterization of ginsenosides in the roots and rhizomes of Panax ginseng by UPLC-DAD-QTOF-MS/MS and simultaneous determination of 19 ginsenosides by HPLC-ESI-MS
por: Wang, Hong-Ping, et al.
Publicado: (2016)

Metabolomics Study of Flavonoids of Taxillus chinensis on Different Hosts Using UPLC-ESI-MS/MS
por: Li, Li, et al.
Publicado: (2021)

Determination of 14 Isoflavone Isomers in Natto by UPLC-ESI-MS/MS and Antioxidation and Antiglycation Profiles
por: Xiang, Aoli, et al.
Publicado: (2022)

Development and validation of an UPLC-ESI-MS/MS method for quantification of duvelisib in plasma: application to pharmacokinetic study in rats
por: Darwish, Ibrahim A., et al.
Publicado: (2023)

Simultaneous determination of fourteen components of Gumiganghwal-tang tablet in human plasma by UPLC-ESI-MS/MS and its application to pharmacokinetic study
por: Jeong, Seung-Hyun, et al.
Publicado: (2021)

Randomized double-blinded pilot clinical study of the antidiabetic activity of Balanites aegyptiaca and UPLC-ESI-MS/MS identification of its metabolites
por: Rashad, Hend, et al.
Publicado: (2017)

Identification of Secondary Metabolites from Aspergillus pachycristatus by Untargeted UPLC-ESI-HRMS/MS and Genome Mining
por: Perlatti, Bruno, et al.
Publicado: (2020)

Identification of Insulin Resistance Biomarkers in Metabolic Syndrome Detected by UHPLC-ESI-QTOF-MS
por: Alsoud, Leen Oyoun, et al.
Publicado: (2022)

Profiling the Oxylipin and Endocannabinoid Metabolome by UPLC-ESI-MS/MS in Human Plasma to Monitor Postprandial Inflammation
por: Gouveia-Figueira, Sandra, et al.
Publicado: (2015)

Analysis of Chemical Constituents of Melastoma dodecandrum Lour. by UPLC-ESI-Q-Exactive Focus-MS/MS
por: Wang, Jinfeng, et al.
Publicado: (2017)

Antioxidant and antimicrobial activities and UPLC-ESI-MS/MS polyphenolic profile of sweet orange peel extracts
por: Shehata, Mohamed G., et al.
Publicado: (2021)

Characterization of color variation in bamboo sheath of Chimonobambusa hejiangensis by UPLC-ESI-MS/MS and RNA sequencing
por: Yu, Lei, et al.
Publicado: (2023)

UPLC-ESI-MS/MS and HPTLC Method for Quantitative Estimation of Cytotoxic Glycosides and Aglycone in Bioactivity Guided Fractions of Solanum nigrum L.
por: Chester, Karishma, et al.
Publicado: (2017)

Profiling and Distribution of Metabolites of Procyanidin B2 in Mice by UPLC-DAD-ESI-IT-TOF-MS(n) Technique
por: Xiao, Ying, et al.
Publicado: (2017)

Simultaneous Qualitative Assessment and Quantitative Analysis of Metabolites (Phenolics, Nucleosides and Amino Acids) from the Roots of Fresh Gastrodia elata Using UPLC-ESI-Triple Quadrupole Ion MS and ESI- Linear Ion Trap High-Resolution MS
por: Chen, Sha, et al.
Publicado: (2016)

Determination of Cefixime by a Validated Stability-Indicating HPLC Method and Identification of its Related Substances by LC-MS/MS Studies
por: Talebpour, Zahra, et al.
Publicado: (2013)

Alkaloids in Erythrina by UPLC-ESI-MS and In Vivo Hypotensive Potential of Extractive Preparations
por: Merlugo, Liara, et al.
Publicado: (2015)

Development and validation of an UPLC-ESI-MS/MS method for determination of dehydroevodiamine, limonin, evodiamine, and rutaecarpine in Evodiae Fructus
por: Zhao, Yang, et al.
Publicado: (2014)

Use of UPLC-ESI-MS/MS to quantitate free amino acid concentrations in micro-samples of mammalian milk
por: Roucher, Véronique Ferchaud, et al.
Publicado: (2013)

Rapid differentiation of Xihuangcao from the three Isodon species by UPLC-ESI-QTOF-MS/MS and chemometrics analysis
por: Wong, Lai Lai, et al.
Publicado: (2016)

Lipidomic analysis of skeletal muscle tissues of p53 knockout mice by nUPLC-ESI-MS/MS
por: Park, Se Mi, et al.
Publicado: (2017)

Determination and pharmacokinetic analysis of ticarcillin disodium–clavulanate potassium for injection in rat plasma by UPLC-ESI-MS/MS
por: Wang, Moli, et al.
Publicado: (2020)

UPLC-ESI-MS/MS Based Characterization of Active Flavonoids from Apocynum spp. and Anti-Bacteria Assay
por: Gao, Gang, et al.
Publicado: (2021)

Simultaneous LC-ESI-MS/MS Quantification of Levosimendan and Its Metabolites for Therapeutic Drug Monitoring of Cardiac Surgery Patients
por: Kipka, Hannah, et al.
Publicado: (2022)

A Comparative Study on Analysis of Ginsenosides in American Ginseng Root Residue by HPLC-DAD-ESI-MS and UPLC-HRMS-MS/MS
por: Hsu, Bo-Yang, et al.
Publicado: (2022)

Simultaneous Detection of 14 Microcystin Congeners from Tissue Samples Using UPLC- ESI-MS/MS and Two Different Deuterated Synthetic Microcystins as Internal Standards
por: Altaner, Stefan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_651fa6t250rmf2vhi03v4dhn9u