Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice

Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. Here, we show that elevated aSMase activity and ceramide content were reduced by desipramine treatment in diabetic animals. The inhibitor of aSMase, desipramine, improved vascular dysfunction in db/db mice. High gluco...

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Detalles Bibliográficos
Autores principales: Jiang, Meng, Huang, Shanya, Duan, Wang, Liu, Qiaoshu, Lei, Minxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481240/
https://www.ncbi.nlm.nih.gov/pubmed/30910852
http://dx.doi.org/10.1042/BSR20182144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481240/
https://www.ncbi.nlm.nih.gov/pubmed/30910852
http://dx.doi.org/10.1042/BSR20182144

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