Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size

Quantitative viral outgrowth assays (QVOA) use limiting dilutions of CD4(+) T cells to measure the size of the latent HIV-1 reservoir, a major obstacle to curing HIV-1. Efforts to reduce the reservoir require assays that can reliably quantify its size in blood and tissues. Although QVOA is regarded...

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Detalles Bibliográficos
Autores principales: Rosenbloom, Daniel I. S., Bacchetti, Peter, Stone, Mars, Deng, Xutao, Bosch, Ronald J., Richman, Douglas D., Siliciano, Janet D., Mellors, John W., Deeks, Steven G., Ptak, Roger G., Hoh, Rebecca, Keating, Sheila M., Dimapasoc, Melanie, Massanella, Marta, Lai, Jun, Sobolewski, Michele D., Kulpa, Deanna A., Busch, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481870/
https://www.ncbi.nlm.nih.gov/pubmed/30978183
http://dx.doi.org/10.1371/journal.pcbi.1006849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481870/
https://www.ncbi.nlm.nih.gov/pubmed/30978183
http://dx.doi.org/10.1371/journal.pcbi.1006849

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